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Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion

Abstract Coiled-coil (CC) dimer-forming peptides are attractive designable modules for mediating protein association. Highly stable CCs are desired for biological activity regulation and assay. Here, we report the design and versatile applications of orthogonal CC dimer-forming peptides with a disso...

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Príomhchruthaitheoirí: Tjaša Plaper, Jana Aupič, Petra Dekleva, Fabio Lapenta, Mateja Manček Keber, Roman Jerala, Mojca Benčina
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2021-04-01
Sraith:Scientific Reports
Rochtain ar líne:https://doi.org/10.1038/s41598-021-88315-3
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