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Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism.

The NCoR corepressor plays critical roles in mediating transcriptional repression by both nuclear receptors and non-receptor transcription factors. Alternative mRNA splicing of NCoR produces a series of variants with differing molecular and biological properties. The NCoRω splice-variant inhibits ad...

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Autores principales: Michael L Goodson, Trina A Knotts, Elsie L Campbell, Chelsea A Snyder, Briana M Young, Martin L Privalsky
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2020-01-01
Colección:PLoS ONE
Acceso en línea:https://doi.org/10.1371/journal.pone.0241238
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