Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

Abstract Background Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain unknown and no treatments are available to prevent...

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Principais autores:	Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-09-01
Colecção:	Molecular Neurodegeneration
Assuntos:	Alzheimer’s disease Amyloid APP APP-KI App NL-G-F BACE
Acesso em linha:	http://link.springer.com/article/10.1186/s13024-020-00393-5
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