The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177

NO production catalysed by eNOS (endothelial nitric-oxide synthase) plays an important role in the cardiovascular system. A variety of agonists activate eNOS through the Ser1177 phosphorylation concomitant with Thr495 dephosphorylation, resulting in increased ·NO production with a basal level of cal...

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Bibliografiske detaljer

Principais autores:	Pei‑Rung Wu, Bo‑Rui Chen, Chi‑Chun Hsieh, Wei‑Chung Lin, Kenneth K. Wu, Yeukuang Hwu, Pei‑Feng Chen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Portland Press 2014-08-01
Serier:	Bioscience Reports
Fag:	autoinhibitory element calcium/calmodulin CaM-binding domain endothelial nitric-oxide synthase mobility shift gel phosphorylation/dephosphorylation
Online adgang:	http://www.bioscirep.org/bsr/034/e129/bsr034e129.htm
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