Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation

Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Linoleic acid (18:2n6, LA) is an essential n-6 PUFA which is converted to arachidonic acid (20:4n6, AA) by desaturation and elongation via...

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Detalhes bibliográficos

Principais autores:	Victor Samokhvalov, K. Lockhart Jamieson, Ahmed M. Darwesh, Hedieh Keshavarz-Bahaghighat, Tim Y. T. Lee, Matthew Edin, Fred Lih, Darryl C. Zeldin, John M. Seubert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	soluble epoxide hydrolase cardiac function mitochondrial function LPS inflammation
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2018.01572/full
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