Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth

In this study, we propose lactucopicrin (LCTP), a natural sesquiterpene lactone from Lactucavirosa, as a molecule able to control the growth of glioblastoma continuous cell line U87Mg. The IC50 of U87Mg against LCTP revealed a strong cytotoxic effect. Daily administration of LCTP showed a dose and t...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Rossella Rotondo, Maria Antonietta Oliva, Sabrina Staffieri, Salvatore Castaldo, Felice Giangaspero, Antonietta Arcella
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-12-01
Schriftenreihe:	Molecules
Schlagworte:	glioblastoma (GBM) lactucopicrin (LCTP) temozolomide (TMZ) autophagy oxidative stress NF-κB
Online-Zugang:	https://www.mdpi.com/1420-3049/25/24/5843
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