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Insulin-loaded PLGA microspheres for glucose-responsive release

Porous poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared, loaded with insulin, and then coated in poly(vinyl alcohol) (PVA) and a novel boronic acid-containing copolymer [poly(acrylamide phenyl boronic acid-co-N–vinylcaprolactam); p(AAPBA-co-NVCL)]. Multilayer microspheres were generat...

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Principais autores: Jun-Zi Wu, Gareth R. Williams, He-Yu Li, Dong-Xiu Wang, Shu-De Li, Li-Min Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2017-01-01
coleção:Drug Delivery
Assuntos:
porous microspheres
layer-by-layer
glucose sensitive
sustained release
smart drug delivery system
Acesso em linha:http://dx.doi.org/10.1080/10717544.2017.1381200
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