Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice

Abstract Tryptophan (Trp) is an essential amino acid, whose metabolism is a key gatekeeper of intestinal homeostasis. Yet, its systemic effects, particularly on atherosclerosis, remain unknown. Here we show that high-fat diet (HFD) increases the activity of intestinal indoleamine 2, 3-dioxygenase 1...

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Principais autores:	Mouna Chajadine, Ludivine Laurans, Tobias Radecke, Nirmala Mouttoulingam, Rida Al-Rifai, Emilie Bacquer, Clara Delaroque, Héloïse Rytter, Marius Bredon, Camille Knosp, José Vilar, Coralie Fontaine, Nadine Suffee, Marie Vandestienne, Bruno Esposito, Julien Dairou, Jean Marie Launay, Jacques Callebert, Alain Tedgui, Hafid Ait-Oufella, Harry Sokol, Benoit Chassaing, Soraya Taleb
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2024-07-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-024-50807-x
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