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Evaluation of clinical effects and plasma metabolomic profiles after the administration of grapiprant in dogs affected by osteoarthritis: a prospective, off–on–off, clinical study

IntroductionOsteoarthritis (OA) is a prevalent cause of chronic pain and impaired mobility in dogs. Grapiprant, an EP4 prostaglandin receptor antagonist, represents a novel therapeutic option with a favorable safety profile compared to traditional NSAIDs.AimTo evaluate the clinical efficacy of grapi...

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Main Authors: Claudia Piemontese, Chiara Roberta Girelli, Marzia Stabile, Luca Lacitignola, Agata Fraccascia, Antonio Crovace, Francesco Paolo Fanizzi, Francesco Staffieri
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-06-01
Series:Frontiers in Veterinary Science
Subjects:
osteoarthritis
grapiprant
pain
inflammation
metabolomic
dog
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2026.1811478/full
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