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Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy

Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We present a case of meningococcal sepsis in a p...

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Principais autores: Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, Seppo Meri
Format: Artigo
Sprog:Inglês
Udgivet: Centers for Disease Control and Prevention 2025-03-01
Serier:Emerging Infectious Diseases
Fag:
Meningococcal
sepsis
paroxysmal nocturnal hemoglobinuria
pegcetacoplan
Neisseria meningitidis
complement
Online adgang:https://wwwnc.cdc.gov/eid/article/31/3/24-1182_article
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