Biological Role of Pazopanib and Sunitinib Aldehyde Derivatives in Drug-Induced Liver Injury

Tyrosine kinase inhibitors pazopanib and sunitinib are both used to treat advanced renal cell carcinoma but expose patients to an increased risk of hepatotoxicity. We have previously identified two aldehyde derivatives for pazopanib and sunitinib (P-CHO and S-CHO, respectively) in liver microsomes....

Descrición completa

Detalles Bibliográficos

Principais autores:	Maud Maillard, Cécile Arellano, Christelle Vachoux, Christine Chevreau, Nicolas J. Cabaton, Frédéric Pont, Nathalie Saint-Laurent, Thierry Lafont, Etienne Chatelut, Fabienne Thomas
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-09-01
Series:	Metabolites
Assuntos:	aldehyde hepatotoxicity pazopanib reactive metabolites sunitinib
Acceso en liña:	https://www.mdpi.com/2218-1989/12/9/852
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!