A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against <i>S. pneumoniae</i> in Mice

Combining amoxicillin with the immunostimulatory toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) represents an innovative approach for enhancing antibacterial treatment success. Exploiting pharmacokinetic and pharmacodynamic data from an infection model of <i>Streptococcus pneumoniae</i>...

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Autori principali:	Sebastian Franck, Robin Michelet, Fiordiligie Casilag, Jean-Claude Sirard, Sebastian G. Wicha, Charlotte Kloft
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-03-01
Serie:	Pharmaceutics
Soggetti:	pharmacometric PK/PD modelling time-to-event modelling amoxicillin MPLA immunomodulation murine model
Accesso online:	https://www.mdpi.com/1999-4923/13/4/469
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