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MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathway

Abstract Background Cardiomyocyte apoptosis is a common pathological manifestation that occurs in several heart diseases. This study aimed to explore the mechanism of microRNA-486 (miR-486) in cardiomyocyte apoptosis by interfering with the p53-activated BCL-2 associated mitochondrial pathway. Metho...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yuhan Sun, Qiang Su, Lang Li, Xiantao Wang, Yuanxi Lu, Jiabao Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-05-01
Schriftenreihe:BMC Cardiovascular Disorders
Schlagworte:
Cardiomyocyte
Apoptosis
miR-486
P53
BCL-2 pathway
Online-Zugang:http://link.springer.com/article/10.1186/s12872-017-0549-7
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