A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.

The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic fungal species suc...

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Bibliografski detalji

Glavni autori:	Jayme L Dahlin, Rondedrick Sinville, Jonathan Solberg, Hui Zhou, Junhong Han, Subhashree Francis, Jessica M Strasser, Kristen John, Derek J Hook, Michael A Walters, Zhiguo Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2013-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC3832525?pdf=render
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