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Heparin Dosing Regimen Optimization in Veno-Arterial Extracorporeal Membrane Oxygenation: A Pharmacokinetic Analysis

Background. Unfractionated heparin is administered in patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Anticoagulation monitoring is recommended, with an anti-activated factor X (anti-Xa) targeting 0.3 to 0.7 IU/mL. Owing to heparin’s heterogeneous pharmacokinetic pro...

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Hoofdauteurs: Julien Lanoiselée, Jérémy Mourer, Marie Jungling, Serge Molliex, Lise Thellier, Julien Tabareau, Emmanuelle Jeanpierre, Emmanuel Robin, Sophie Susen, Benoit Tavernier, André Vincentelli, Edouard Ollier, Mouhamed Djahoum Moussa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2024-06-01
Reeks:Pharmaceutics
Onderwerpen:
heparin
extracorporeal membrane oxygenation (ECMO)
pharmacokinetics
anticoagulation
anti-Xa
Online toegang:https://www.mdpi.com/1999-4923/16/6/770
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