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Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

Tropodithietic acid (TDA) is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. We have synthesised several structural analogues of TDA and used them in bioactivity tests against Staphylococcus aureu...

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Principais autores: Patrick Rabe, Tim A. Klapschinski, Nelson L. Brock, Christian A. Citron, Paul D’Alvise, Lone Gram, Jeroen S. Dickschat
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2014-08-01
Serier:Beilstein Journal of Organic Chemistry
Fag:
antibiotics
natural products
Roseobacter
SAR study
tropodithietic acid
tropone
Online adgang:https://doi.org/10.3762/bjoc.10.188
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