Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus

One of the oldest mechanisms of immune defense against pathogens is through detection of foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the cytosol heralds a potential threat. The cGAS-STING pathway is one of the most important cytosolic DNA sensing pathways and...

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Principais autores:	Holly Wobma, Daniel S. Shin, Janet Chou, Fatma Dedeoğlu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-05-01
סדרה:	Frontiers in Immunology
נושאים:	interferon JAK inhibitor lupus autoinflammatory STING-Associated Vasculopathy of Infancy Copa Syndrome
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.905109/full
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