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Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblasts

Non-homologous end-joining (NHEJ) is a predominant pathway for the repair of DNA double-strand breaks (DSB). It inhibits the efficiency of homologous recombination (HR) by competing for DSB targets. To improve the efficiency of HR, multiple CRISPR interference (CRISPRi) and Natronobacterium gregoryi...

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Autori principali: Guo-ling LI, Rong QUAN, Hao-qiang WANG, Xiao-fang RUAN, Jian-xin MO, Cui-li ZHONG, Hua-qiang YANG, Zi-cong LI, Ting GU, De-wu LIU, Zhen-fang WU, Geng-yuan CAI, Xian-wei ZHANG
Natura: Artigo
Lingua:Inglês
Pubblicazione: KeAi Communications Co., Ltd. 2019-02-01
Serie:Journal of Integrative Agriculture
Soggetti:
homologous recombination
non-homologous end-joining
CRISPRi
NgAgoi
KU70
KU80
Accesso online:http://www.sciencedirect.com/science/article/pii/S2095311918621501
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