Engineering CCR2/IFN-γ overexpression in enucleated mesenchymal stem cells enhances therapy for rheumatoid arthritis

Abstract Mesenchymal stem cells (MSCs) offer a promising therapy for rheumatoid arthritis (RA). However, their therapeutic potential is hindered by initial trapping in lung capillaries, which may reduce efficacy and increase risks of complications, such as unwanted differentiation and malignancy. Ad...

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Detalhes bibliográficos

Principais autores:	Yue Sui, Zixi Pu, Naixue Yang, Yifei Luo, Yalian Sa, Qi Qi, Li Tan, Yaping Yan, Wei Si
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
Colecção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-025-09248-5
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