Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum,...
Sparad:
| Huvudupphov: | , , , , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Nature Portfolio
2020-02-01
|
| Serie: | Nature Communications |
| Länkar: | https://doi.org/10.1038/s41467-020-14855-3 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|