The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling

Abstract Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells (BMSCs) is lost upon aging is still unclear. Here, we found that the R...

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Hlavní autoři:	Jinlong Suo, Sihai Zou, Jinghui Wang, Yujiao Han, Lingli Zhang, Chenchen Lv, Bo Jiang, Qian Ren, Long Chen, Lele Yang, Ping Ji, Xianyou Zheng, Ping Hu, Weiguo Zou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2022-03-01
Edice:	Bone Research
On-line přístup:	https://doi.org/10.1038/s41413-022-00202-3
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