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Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis

Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical manifestations. Although parasites influence disease severity, cytolytic CD8+ T cell responses mediate disease. Although these responses originate in the lymph node, we found that expression of the cytolytic eff...

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Hoofdauteurs: Erin A. Fowler, Camila Farias Amorim, Klauss Mostacada, Allison Yan, Laís Amorim Sacramento, Rae A. Stanco, Emily D.S. Hales, Aditi Varkey, Wenjing Zong, Gary D. Wu, Camila I. de Oliveira, Patrick L. Collins, Fernanda O. Novais
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2024-07-01
Reeks:The Journal of Clinical Investigation
Onderwerpen:
Infectious disease
Inflammation
Online toegang:https://doi.org/10.1172/JCI177992
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