Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine.
Oncolytic reovirus is a potential therapeutic for colorectal cancer patients with a mutant KRAS gene. Reovirus hijacks the autophagic machinery and preferentially induces apoptosis in patients with a KRAS mutation. However, reovirus on its own is not currently a viable treatment and requires enhance...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science (PLoS)
2025-01-01
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| Edice: | PLoS ONE |
| On-line přístup: | https://doi.org/10.1371/journal.pone.0326029 |
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