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C9orf72-derived dipeptide repeat proteins poly-PR disrupt membrane excitability and synaptic function in cortical neurons

Amyotrophic lateral sclerosis (ALS) is one of the most fatal neurodegenerative disease, with the most common genetic form of the ALS is associated with hexanucleotide GGGGCC repeat expansions in the first intron of C9orf72 gene. Cortical hyperexcitability is one of the symptoms reported in several f...

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Principais autores: Shao-Ming Wang, Jui-Cheng Chan, Engkarat Supapatarnun, Chao-Yi Tsai, Phan Thi Ngoc Lan, Eddie Feng-Ju Weng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-04-01
coleção:Neurobiology of Disease
Assuntos:
Amyotrophic lateral sclerosis
C9orf72
Poly-PR
Hyperexcitability
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996126000641
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