Interrogating the Involvement of Autophagy, Senescence, and the Immune System in the Actions of Sacituzumab Govitecan as an Anticancer Agent

Antibody-drug conjugates (ADCs) are an emerging class of cancer therapeutics comprised of a tumor-targeting antibody linked to a cytotoxic payload. Sacituzumab govitecan (SG or IMMU-132) is comprised of a trophoblast cell-surface antigen 2 (TROP-2)-directed antibody linked to the topoisomerase 1 inh...

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Autors principals:	Melanie M. Sinanian, Eesha Chakraborty, Ahmed M. Elshazly, Shady Azzam, Nada Nassif, David A. Gewirtz
Format:	Artigo
Idioma:	Inglês
Publicat:	IMR Press 2025-11-01
Col·lecció:	Frontiers in Bioscience-Landmark
Matèries:	antibody-drug conjugates sacituzumab govitecan trop-2 autophagy senescence immune system drug combinations
Accés en línia:	https://www.imrpress.com/journal/FBL/30/11/10.31083/FBL39310
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