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The budding yeast Fkh1 Forkhead associated (FHA) domain promotes a G1-chromatin state and the activity of chromosomal DNA replication origins.

In Saccharomyces cerevisiae, the forkhead (Fkh) transcription factor Fkh1 (forkhead homolog) enhances the activity of many DNA replication origins that act in early S-phase (early origins). Current models posit that Fkh1 acts directly to promote these origins' activity by binding to origin-adjacent...

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Principais autores: Timothy Hoggard, Erika Chacin, Allison J Hollatz, Christoph F Kurat, Catherine A Fox
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Genetics
Acceso en liña:https://doi.org/10.1371/journal.pgen.1011366
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