Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

ABSTRACT In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previously we discovered bacteriophage-encoded Cas9-spe...

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Hlavní autoři:	Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, Erik J. Sontheimer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2018-12-01
Edice:	mBio
Témata:	CRISPR Cas9 type II-C anti-CRISPR crRNA
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.02321-18
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