Shared germline-biased plasmablast clonotypes shape early neutralizing antibody responses during acute Chikungunya virus infection

IntroductionChikungunya virus (CHIKV) infection causes acute febrile illness and severe joint inflammation, with some patients progressing to chronic arthritis. Early isotype-switched neutralizing antibody (nAb) responses have been associated with protection from chronic arthritis, but the cellular...

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Bibliografiske detaljer

Principais autores:	Kritika Dixit, Kaustuv Nayak, Manpreet Kaur Saini, Sofia Qamar, Prashant Bajpai, Elluri Seetharami Reddy, Sahil Ameer, Vikas Dhar Dubey, Muneeb Pervez, Sagar Kohli, Kamalvishnu Gottimukkala, Shipra Gupta, Naushad Khan, Deepti Maheshwari, Nawaz SM Akhtar, Yadya M. Chawla, Ramesh Chandra Rai, Rohit Sagar, Mohammad Islamuddin, Wajihul Hasan Khan, Nimisha Mishra, Ashok Kumar Patel, Sujatha Sunil, Rakesh Lodha, Vineet Jain, Pratima Ray, Kaja Murali-Krishna, Keshav Saini, Sanjeev Kumar, Anmol Chandele
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2026-06-01
Serier:	Frontiers in Immunology
Fag:	acute viral infection Chikungunya virus germline antibodies human monoclonal antibodies memory B cells neutralizing antibodies
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1846926/full
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