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Underground isoleucine biosynthesis pathways in E. coli

The promiscuous activities of enzymes provide fertile ground for the evolution of new metabolic pathways. Here, we systematically explore the ability of E. coli to harness underground metabolism to compensate for the deletion of an essential biosynthetic pathway. By deleting all threonine deaminases...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Charles AR Cotton, Iria Bernhardsgrütter, Hai He, Simon Burgener, Luca Schulz, Nicole Paczia, Beau Dronsella, Alexander Erban, Stepan Toman, Marian Dempfle, Alberto De Maria, Joachim Kopka, Steffen N Lindner, Tobias J Erb, Arren Bar-Even
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2020-08-01
Schriftenreihe:eLife
Schlagworte:
underground metabolism
promiscuous enzymes
methionine biosynthesis
pyruvate formate-lyase
formate assimilation
Online-Zugang:https://elifesciences.org/articles/54207
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