Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes

ABSTRACT Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. Pyrin contains oligomerization domains and is negatively regulated by phosphorylation of two residues, S205 and S241 (murin...

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Hlavní autoři:	Haleema S. Malik, Flora Magnotti, Nicole A. Loeven, Jose M. Delgado, Arminja N. Kettenbach, Thomas Henry, James B. Bliska
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2023-10-01
Edice:	mBio
Témata:	phosphoprotein phosphatase pyrin inflammasome phagocyte
On-line přístup:	https://journals.asm.org/doi/10.1128/mbio.02066-23
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