2342 Protein production as an early pharmacodynamics biomarker for RNA-targeting therapies

OBJECTIVES/SPECIFIC AIMS: We aimed to develop an assay to measure new protein synthesis after Antisense Oligonucleotide treatment, which we hypothesized to be the earliest biochemical identification of RNA-targeting therapy efficacy. METHODS/STUDY POPULATION: We treated 2 transgenic animal models ex...

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Detalhes bibliográficos

Principais autores:	Wade K. Self, Kathleen Schoch, James Bollinger, Tracy Cole, Holly Kordasiewicz, Randall Bateman, Timothy Miller
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cambridge University Press 2018-06-01
coleção:	Journal of Clinical and Translational Science
Acesso em linha:	https://www.cambridge.org/core/product/identifier/S2059866118001103/type/journal_article
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