3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase

Abstract Advances in X-ray crystallography and cryogenic electron microscopy (cryo-EM) offer the promise of elucidating functionally relevant conformational changes that are not easily studied by other biophysical methods. Here we show that 3D variability analysis (3DVA) of the cryo-EM map for wild-...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Adriana Coricello, Alanya J. Nardone, Antonio Lupia, Carmen Gratteri, Matthijn Vos, Vincent Chaptal, Stefano Alcaro, Wen Zhu, Yuichiro Takagi, Nigel G. J. Richards
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2024-12-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/s41467-024-54912-9
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