A spectrum of cysteine mutations in fibulin-3 highlight its disulfide bonding complexity and potential to induce ER stress

Abstract Fibulin-3 (FBLN3), also known as EFEMP1, is a secreted extracellular matrix (ECM) glycoprotein that contains forty cysteine residues. These cysteines, which are distributed across one atypical and five canonical calcium-binding epidermal growth factor (EGF) domains, are important for regula...

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Egile Nagusiak:	Gracen E. Collier, Anna L. Roovers, John D. Hulleman
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-08-01
Saila:	Scientific Reports
Gaiak:	EFEMP1 Fibulin-3 FBLN3 Protein folding Disulfide bonds
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-025-14561-4
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