Immune-Metabolic Interactions in the Degenerative Retina: A Systems Biology Approach Based on Diabetic Retinopathy

Diabetic retinopathy (DR) is increasingly recognized as a complex neurovascular degenerative disorder driven by intertwined immune and metabolic disturbances within the retinal microenvironment. Chronic hyperglycemia induces metabolic stress, mitochondrial dysfunction, and oxidative imbalance, which...

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Auteurs principaux:	Francesco Cappellani, Caterina Gagliano, Cosimo Mazzotta, Fabiana D’Esposito, Alessandro Avitabile, Giuseppe Gagliano, Daniele Tognetto, Marco Zeppieri
Format:	Artigo
Langue:	Inglês
Publié:	IMR Press 2026-05-01
Collection:	Frontiers in Bioscience-Landmark
Sujets:	diabetic retinopathy neurovascular unit microglia inflammation mitochondrial dysfunction advanced glycation end products complement system systems biology
Accès en ligne:	https://www.imrpress.com/journal/FBL/31/5/10.31083/FBL49588
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