Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma

BackgroundUnderstanding the spatial heterogeneity of the tumor microenvironment (TME) in pancreatic cancer (PC) remains challenging.MethodsIn this study, we performed spatial transcriptomics (ST) to investigate the gene expression features across one normal pancreatic tissue, PC tissue, adjacent tum...

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Bibliografische Detailangaben

Hauptverfasser:	Zhangyong Ren, Bing Pan, Fangfei Wang, Shaocheng Lyu, Jialei Zhai, Xiumei Hu, Zhe Liu, Lixin Li, Ren Lang, Qiang He, Xin Zhao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-04-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	pancreatic ductal adenocarcinoma spatial transcriptomics tumor microenvironment heterogeneity cancer-associated fibroblasts
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1112576/full
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