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Systems genetics of lifespan and senescence in Drosophila melanogaster

Abstract Background As populations age, the number of people with age-related chronic diseases increases, causing significant social, economic and health problems. Natural variation in lifespan depends on multiple interacting genes and environmental exposures. Its short generation time and many reso...

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Main Authors: Maryam Nasiri Aghdam, Desireé Unselt, Maria E. Adonay, Tatiana V. Morozova, Mary Anna Carbone, Gunjan H. Arya, Lavanya Turlapati, Vijay Shankar, Robert R. H. Anholt, Trudy F. C. Mackay
Format: Artigo
Language:Inglês
Published: BMC 2025-12-01
Series:BMC Biology
Subjects:
Aging
Drosophila Genetic Reference Panel (DGRP)
XQTLs
Transcriptional senescence
Context-specific effects
Interaction networks
Online Access:https://doi.org/10.1186/s12915-025-02485-4
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