Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor

Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity. As a result, compounds 3o, 3p, and 3s with a 1,3-diaryl-pyrrole skeleton showe...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shouyuan Sun, Tao Shi, Yan Peng, Honghua Zhang, Linsheng Zhuo, Xue Peng, Qien Li, Manxia Wang, Shuzhi Wang, Zhen Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-12-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	substituted pyrroles acetylcholinesterase butyrylcholinesterase molecular docking enzyme kinetic
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1043397/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!