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Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification

BackgroundNeuromelanin- and iron-sensitive MRI studies in Parkinson's disease (PD) are limited by small sample sizes and lack detailed clinical correlation. In a large case–control PD cohort, we evaluated the diagnostic accuracy of quantitative iron–neuromelanin MRI parameters from the substantia ni...

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Principais autores: Septian Hartono, Robert Chun Chen, Thomas Welton, An Sen Tan, Weiling Lee, Peik Yen Teh, Celeste Chen, Wenlu Hou, Wei Ping Tham, Ee Wei Lim, Kumar M. Prakash, Yao-Chia Shih, Kuan Jin Lee, Louis C. S. Tan, Eng King Tan, Ling Ling Chan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-11-01
Serier:Frontiers in Aging Neuroscience
Fag:
Parkinson's disease
MRI
substantia nigra
classification
comparative study
correlation analysis
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1287917/full
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