Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes

Summary: We investigate the molecular landscape of locally advanced nasopharyngeal carcinoma (LA-NPC) subtypes: limited (L), ascending (A), descending (D), and ascending-descending (AD). Using a cohort of 994 patients, we perform germline and somatic whole-exome sequencing (WES), transcriptomic prof...

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Detalhes bibliográficos

Principais autores:	Eugenia Li Ling Yeo, Boon Hao Hong, Shi Hui Tay, Jialing Neo, Enya Hui Wen Ong, Wen Min Chow, Kah Min Tan, Kar Perng Low, Adelene Yen Ling Sim, Tianzhu Lu, Xin Zhang, Luo Huang, Janice Ser Huey Tan, Joseph Tien Seng Wee, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Sze Yarn Sin, Xin Xiu Sam, Jacqueline Siok Gek Hwang, Tony Kiat Hon Lim, Jia-Ying Joey Lee, Lit-Hsin Loo, Khee Chee Soo, Narayanan Gopalakrishna Iyer, Kwok Seng Loh, Joshua K. Tay, Jianjun Liu, Mei Kim Ang, Joe Poh Sheng Yeong, Jin Xin Bei, Sze Huey Tan, Darren Wan Teck Lim, Melvin Lee Kiang Chua
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-06-01
coleção:	Cell Reports Medicine
Assuntos:	nasopharyngeal carcinoma ascending descending genomics tumor immune microenvironment
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666379125002162
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