Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Abstract Structural resolution of protein interactions enables mechanistic and functional studies as well as interpretation of disease variants. However, structural data is still missing for most protein interactions because we lack computational and experimental tools at scale. This is particularly...

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Главные авторы:	Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Springer Nature 2024-01-01
Серии:	Molecular Systems Biology
Предметы:	AlphaFold Protein Interaction Interface Prediction Linear Motifs Benchmarking Experimental Validation
Online-ссылка:	https://doi.org/10.1038/s44320-023-00005-6
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