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Preclinical Studies on Intestinal Administration of Antisense Oligonucleotides as a Model for Oral Delivery for Treatment of Duchenne Muscular Dystrophy

Antisense oligonucleotides (AONs) used to reframe dystrophin mRNA transcripts for Duchenne muscular dystrophy (DMD) patients are tested in clinical trials. Here, AONs are administered subcutaneously and intravenously, while the less invasive oral route would be preferred. Oral delivery of encapsulat...

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Furkejuvvon:
Váldodahkkit: Maaike van Putten, Courtney Young, Sjoerd van den Berg, Amanda Pronk, Margriet Hulsker, Tatyana G Karnaoukh, Rick Vermue, Ko Willems van Dijk, Sjef de Kimpe, Annemieke Aartsma-Rus
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2014-01-01
Ráidu:Molecular Therapy: Nucleic Acids
Fáttát:
antisense oligonucleotides
bioavailability
Duchenne muscular dystrophy
dystrophin
oral administration
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S216225311630350X
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