DNA Sliding Clamps as Therapeutic Targets

Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA clamps, proliferating cell nuclear antigen (P...

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Autores principales:	Amanda S. Altieri, Zvi Kelman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2018-10-01
Colección:	Frontiers in Molecular Biosciences
Materias:	β-clamp DNA clamp DNA sliding clamp proliferating cell nuclear antigen PCNA therapeutic
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fmolb.2018.00087/full
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