In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model

We assessed electrophysiological effects of an atypical antipsychotic drug paliperidone in acute atrioventricular block rabbits. Intravenous administration of paliperidone at a clinically relevant dose (0.06 mg/kg) hardly affected the QT interval or monophasic action potential (MAP) duration, and th...

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Detalhes bibliográficos

Principais autores:	Mihoko Hagiwara, Ryuichi Kambayashi, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-09-01
coleção:	Journal of Pharmacological Sciences
Assuntos:	Paliperidone QT prolongation Torsades de pointes Atrioventricular block
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1347861316300536
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