Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant (foz/foz) mice were a fed high-fat (23%) diet containing 0.2% chol...

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Autors principals:	George N. Ioannou, Derrick M. Van Rooyen, Christopher Savard, W. Geoffrey Haigh, Matthew M. Yeh, Narci C. Teoh, Geoffrey C. Farrell
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-02-01
Col·lecció:	Journal of Lipid Research
Matèries:	crown-like structure caspase 1 lipotoxicity nonalcoholic steatohepatitis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0022227520356133
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