CRISPR-induced exon skipping is dependent on premature termination codon mutations

Abstract In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in prema...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Tingting Sui, Yuning Song, Zhiquan Liu, Mao Chen, Jichao Deng, Yuanyuan Xu, Liangxue Lai, Zhanjun Li
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2018-10-01
Sarja:	Genome Biology
Aiheet:	Exon skipping PTC CRISPR/Cas9 Rabbits
Linkit:	http://link.springer.com/article/10.1186/s13059-018-1532-z
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