Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated. We aim to leverage an integrative analytical pipeline to identify novel IDD risk genes from...

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Автори:	Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Cheng Dong, Zhengya Zhu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2025-11-01
Серія:	Frontiers in Medicine
Предмети:	intervertebral disc disorder transcriptome-wide association study proteome-wide association study genome-wide association study validation study
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1698050/full
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