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Long-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield.

Antidepressant drugs are usually administered for long time for the treatment of major depressive disorder. However, they are also prescribed in several additional psychiatric conditions as well as during long term maintenance treatments. Antidepressants induce adaptive changes in several forebrain...

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Principais autores: Francisco J Rubio, Estibaliz eAmpuero, Rodrigo eSandoval, Jorge eToledo, Floria ePancetti, Ursula eWyneken
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-05-01
Serier:Frontiers in Cellular Neuroscience
Fag:
Dendritic Spines
glutamate receptors
LTP
LTD
Antidepressants
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00066/full
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