Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail to target desired cells. Thus, local and targ...

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Bibliografische Detailangaben

Hauptverfasser:	Sonia Golombek, Martin Pilz, Heidrun Steinle, Efrat Kochba, Yotam Levin, Dominique Lunter, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2018-06-01
Schriftenreihe:	Molecular Therapy: Nucleic Acids
Schlagworte:	synthetic mRNA microneedles intradermal delivery protein expression
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2162253118300350
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