FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

Summary: Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human lung adenocarcinoma cells remain largely unknown. Here, we identify...

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Detalhes bibliográficos

Principais autores:	Mariana Cooke, Gabriel Kreider-Letterman, Martin J. Baker, Suli Zhang, Neil T. Sullivan, Evgeniy Eruslanov, Martin C. Abba, Silvia M. Goicoechea, Rafael García-Mata, Marcelo G. Kazanietz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
coleção:	Cell Reports
Assuntos:	Rac1 Rac-GEF EGFR lung cancer AXL FARP1
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124721013759
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