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Preparation and Evaluation of Eudragit L100-PEG Proliponiosomes for Enhanced Oral Delivery of Celecoxib

PEGylated Eudragit L100 (ELP)-containing proliponiosomes (PLNs) were developed for improved oral delivery of celecoxib (CXB). The successful introduction of PEG 2000 or 5000 to Eudragit L100 (EL) was confirmed via proton nuclear magnetic resonance analysis of which calculated molar substitution rati...

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Autori principali: Min-Hwan Kim, Dong Hyun Kim, Duy-Thuc Nguyen, Han Sol Lee, Nae-Won Kang, Min-Jun Baek, Jiseon An, So-Yeol Yoo, Yong-Hyeon Mun, Wonhwa Lee, Ki-Taek Kim, Cheong-Weon Cho, Jae-Young Lee, Dae-Duk Kim
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-07-01
Serie:Pharmaceutics
Soggetti:
proliponiosomes
Eudragit L100
PEGylation
celecoxib
oral bioavailability
Accesso online:https://www.mdpi.com/1999-4923/12/8/718
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